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Ephedra

Common Names: 
ephedra, Chinese ephedra, ma huang
Latin Name: 
Ephedra sinica

ephedra_foster.jpg

Ephedra

© Steven Foster

On this page:

  • Sources
  • Introduction

    This fact sheet provides basic information about ephedra—common names, what the science says, potential side effects and cautions, and resources for more information.

    Ephedra is an evergreen shrub-like plant native to Central Asia and Mongolia. The principal active ingredient, ephedrine, is a compound that can powerfully stimulate the nervous system and heart. Ephedra has been used for more than 5,000 years in China and India to treat conditions such as colds, fever, flu, headaches, asthma, wheezing, and nasal congestion. More recently, ephedra was used as an ingredient in dietary supplements for weight loss, increased energy, and enhanced athletic performance.

    The dried stems and leaves of the ephedra plant have been used to create capsules, tablets, tinctures, and teas.

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    What the Science Says

    • An NCCAM-funded study that analyzed phone calls to poison control centers found a higher rate of side effects from ephedra, compared with other herbal products.
    • Other studies and systematic reviews have found an increased risk of heart, psychiatric, and gastrointestinal problems, as well as high blood pressure and stroke, with ephedra use.
    • According to the U.S. Food and Drug Administration (FDA), there is little evidence of ephedra’s effectiveness, except for short-term weight loss. However, the increased risk of heart problems and stroke outweighs any benefits.

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    Side Effects and Cautions

    • In 2004, the FDA banned the U.S. sale of dietary supplements containing ephedra. The FDA found that these supplements had an unreasonable risk of injury or illness—particularly cardiovascular complications—and a risk of death. The ban does not apply to traditional Chinese herbal remedies or to products like herbal teas regulated as conventional foods.1
    • Between 1995 and 1997, the FDA received more than 900 reports of possible ephedra toxicity. Serious adverse events such as stroke, heart attack, and sudden death were reported in 37 cases.
    • Using ephedra may worsen many health conditions such as cardiovascular disease, kidney disease, and diabetes.
    • Ephedra may cause seizures in otherwise healthy people as well as in people with seizure disorders.
    • Taking ephedra can also result in anxiety, difficulty urinating, dry mouth, headache, heart damage, high blood pressure, irregular heart rhythms, irritation of the stomach, kidney stones, nausea, psychosis, restlessness, sleep problems, and tremors.
    • Women who are pregnant or breastfeeding and children should avoid taking ephedra.
    • Ephedra use may lead to serious health problems when used with other dietary supplements or medicines.
    • Combining ephedra with caffeine increases the risk of potentially serious side effects.
    • Tell all your health care providers about any complementary health practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care. For tips about talking with your health care providers about complementary and alternative medicine, see NCCAM's Time to Talk campaign.

    Search the scientific literature for potential herb-drug interactions

    1 Products regulated as drugs that contain chemically synthesized ephedrine are not dietary supplements and are not covered by this rule. These include drugs used for the short-term treatment of asthma, bronchitis, and allergic reactions.

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    Sources

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    For More Information

    NCCAM Clearinghouse

    The NCCAM Clearinghouse provides information on NCCAM and complementary health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.

    Toll-free in the U.S.: 
    1-888-644-6226
    TTY (for deaf and hard-of-hearing callers): 
    1-866-464-3615
    E-mail: 

    PubMed®

    A service of the National Library of Medicine (NLM), PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals.

    Office of Dietary Supplements (ODS), National Institutes of Health (NIH)

    ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Its resources include publications (such as Dietary Supplements: What You Need to Know), fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements), and the PubMed Dietary Supplement Subset.

    PubMed Dietary Supplement Subset: ods.od.nih.gov/Research/PubMed_Dietary_Supplement_Subset.aspx

    E-mail: 

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    This publication is not copyrighted and is in the public domain. Duplication is encouraged.

    NCCAM has provided this material for your information. It is not intended to substitute for the medical expertise and advice of your primary health care provider. We encourage you to discuss any decisions about treatment or care with your health care provider. The mention of any product, service, or therapy is not an endorsement by NCCAM.

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    NCCAM Publication No.: 
    D336
    Created: 
    December 2006
    Updated: 
    June 2013