National Center for Complementary and Alternative Medicine (NCCAM)

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Protective Roles of Grape-Derived Polyphenols in Alzheimer's Disease

Principal Investigator: 
Giulio Maria Pasinetti, M.D., Ph.D.


Mount Sinai School of Medicine Department of Psychiatry
One Gustave L Levy Place Box 1230
New York, NY 10029
United States


This center will conduct preclinical studies to identify natural compounds extracted from grapes, known as polyphenols that might have a protective role in Alzheimer's disease. Using an animal model, the research team will then investigate the biological mechanisms by which these grape-derived compounds may affect changes in the brain that are characteristic of Alzheimer's disease and associated with cognitive decline.

Centers of Excellence for Research on CAM