Spotlight on Clinical Trials
The clinical trials below are among the many NCCAM-sponsored trials that were recruiting at press time. To find out more, go to clinicaltrials.gov (for a specific trial below, enter the identifier).
Treatment of Rheumatoid Arthritis With Marine and Botanical Oils
Both fish oil and borage oil are rich in omega-3 fatty acids, which may have anti-inflammatory properties. The researchers are examining the effectiveness of using these oils--ingested either alone or in combination--to treat rheumatoid arthritis, as well as how they may work in the body.
Identifier: NCT0007298
Principal investigator's institution: University of Massachusetts Medical School, Worcester
The Role of Vitamins C and E in Maintaining Lung Health in People With Asthma
Eosinophils and neutrophils are inflammatory cells in people's airways and lungs. When these cells are activated, they make chemicals called oxidants; this irritates the mucosal cells in the airways, and mucus develops in the lungs. Substances that cause allergic reactions (allergens) can activate the inflammatory cells and thereby worsen asthma symptoms. Vitamins E (alpha-tocopherol) and C (ascorbate) have been shown to lessen the worsening of asthma associated with exposure to ozone (a gas that, at ground level, is an air pollutant and a major ingredient of smog). Enhancing antioxidant and anti-inflammatory defenses in the airways and lungs could hold promise for treating respiratory diseases aggravated by allergies. This study is investigating a combination vitamin E and vitamin C therapy for this purpose.
Identifier: NCT00142610
Principal investigator's institution: University of North Carolina School of Medicine
Black Cohosh Extract in Postmenopausal Breast Health
Black cohosh extract (BCE) is the largest-selling dietary supplement used to treat menopausal symptoms (such as hot flashes). How it may work is not yet clear--some studies indicate it is through the central nervous system, and others, through an estrogen-like effect. This study seeks to find out more about the effects of BCE, especially on the breast and on menopausal symptoms, and whether it increases the risk of developing estrogen-related cancers, such as breast cancer.
Identifier: NCT00064831
Principal investigator's institution: University of Missouri-Columbia
