Roundtable Meeting on Dietary Supplement–Drug Interactions Agenda
Tuesday, March 27, 2012
Neuroscience Building, 6001 Executive Blvd
Rockville, Maryland
- 8:30 a.m.
-
Welcome and Introduction
Josephine Briggs, M.D., National Center for Complementary and Alternative Medicine
Paul Coates, Ph.D., Office of Dietary Supplements
Jeffrey White, M.D., National Cancer Institute - 8:50 a.m.
-
Overview of Workshop/Charge to Attendees
Craig Hopp, Ph.D., National Center for Complementary and Alternative Medicine
- 9:00 a.m.
-
Session I: Obstacles to Drug Interaction Research
Moderator: Craig Hopp, Ph.D., National Center for Complementary and Alternative Medicine
- 9:05 a.m.
- Evaluation of Dietary Supplement–Drug Interactions: Limitations of In Vitro Methods
John Markowitz, Pharm.D., University of Florida - 9:25 a.m.
- Evaluating the Clinical Relevance of Human Dietary Supplement-Drug Interaction Study Designs
Bill Gurley, Ph.D., University of Arkansas - 9:45 a.m.
- Questions and Discussion
- 10:15 a.m.
-
Break
- 10:30 a.m.
-
Session II: Roundtable Discussion on Improved Methodology
Moderator: Shiew-Mei Huang, Ph.D., U.S. Food and Drug Administration
- Are there any computational, i.e. in silico, methods that can be employed?
- Does high throughput screening offer any insight into possible clinical drug interactions?
- How can we make animal models more predictive?
- 11:15 a.m.
-
Session III: Pharmacokinetic Interactions
Moderator: Joseph Betz, Ph.D., Office of Dietary Supplements
- 11:20 a.m.
- Predicting and Interpreting Drug Interactions With Nutrients and Natural Products
David J. Greenblatt, M.D., Tufts University School of Medicine - 11:40 a.m.
- Transport-Mediated Dietary Supplement–Drug Interactions
Reginald Frye, Pharm.D., Ph.D., University of Florida - 12:00 noon
- Discussion
- 12:00 noon
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Lunch
- 1:30 p.m.
-
Session IV: Pharmacodynamic Interactions
Moderator: Jeffrey White, M.D., National Cancer Institute
- 1:35 p.m.
- Botanicals as Adjuvant for Cancer Chemoprevention
Chun-Su Yuan, M.D., Ph.D., University of Chicago - 1:55 p.m.
- Overcoming Therapeutic Resistance by Nutraceuticals
Fazlul Sarkar, Ph.D., Wayne State University - 2:15 p.m.
- Discussion
- 2:45 p.m.
-
Break
- 3:00 p.m.
-
Session V: Roundtable Discussion on the Path Forward
Besides grapefruit juice and St. John’s wort, are there other clinically significant adverse interactions?
- How should supplement/drug interaction research be prioritized?
- Where can NCCAM resources provide the greatest impact?
- How can we best inform the medical community and patient population about the relative risk/benefit of any particular combination?
- What types of research have the greatest potential to impact clinical practice?
- 4:00 p.m.
-
Adjourn
WORKSHOP DISCUSSANTS
- Reginald Frye, Pharm. D., Ph.D., FCCP
- Associate Professor
- Department of Pharmacotherapy and Translational Research
- Associate Director
- University of Florida Center for Pharmacogenomics
- College of Pharmacy
- University of Florida
- Gainesville, FL
- David J. Greenblatt, M.D.
- Louis Lasagna Professor of Pharmacology and Experimental Therapeutics
- Sackler School of Graduate Biomedical Sciences
- Tufts University School of Medicine
- Boston, MA
- Bill Gurley, Ph.D.
- Professor
- Department of Pharmaceutical Sciences
- College of Pharmacy
- University of Arkansas for Medical Sciences
- Little Rock, AR
- Shiew-Mei Huang, Ph.D.
- Deputy Director
- Office of Clinical Pharmacology
- Center for Drug Evaluation and Research
- Food and Drug Administration
- Silver Spring, MD
- John Markowitz, Pharm.D.
- Professor
- Department of Pharmacotherapy and Translational Research
- College of Pharmacy
- University of Florida
- Gainesville, FL
- Mary Paine, Ph.D., R.Ph.
- Assistant Professor
- Department of Pharmacotherapy and Experimental Therapeutics
- Eshelman School of Pharmacy
- University of North Carolina at Chapel Hill
- Chapel Hill, NC
- Fazlul Sarkar, Ph.D.
- Professor
- Department of Cancer Biology
- Karmanos Cancer Center
- Wayne State University
- Detroit, MI
- Chun-Su Yuan, M.D., Ph.D.
- Cyrus Tang Professor, Department of Anesthesia & Critical Care
- Director, Tang Center for Herbal Medicine Research
- Pritzker School of Medicine
- University of Chicago
- Chicago, IL
